30. Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion

  1. Ming Hu2 and
  2. Xiaoling Li3
  1. Cindy Q. Xia,
  2. Chuang Lu and
  3. Suresh K. Balani

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch30

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Xia, C. Q., Lu, C. and Balani, S. K. (2011) Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch30

Editor Information

  1. 2

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 3

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. Drug Metabolism and Pharmacokinetics, Millennium Pharmaceuticals, Inc., 35 Landsdowne Street, Cambridge, MA 02139, USA

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • liver perfusion and primary hepatocytes - studying, drug metabolism and metabolite excretion;
  • liver perfusion model, elucidating mechanisms - of first-pass drug metabolism in liver;
  • primary hepatocytes, recognized - practical models, drug metabolism and transporter interactions

Summary

This chapter contains sections titled:

  • Introduction

  • Liver Perfusion

  • Primary Hepatocytes

  • Organ perfusion versus hepatocyte studies

  • Perspectives

  • Acknowledgments

  • Abbreviations

  • References