4. In Vitro Dissolution of Pharmaceutical Solids

  1. Ming Hu3 and
  2. Xiaoling Li4
  1. Josephine L. P. Soh1 and
  2. Paul W. S. Heng2

Published Online: 5 JUL 2011

DOI: 10.1002/9781118067598.ch4

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

How to Cite

Soh, J. L. P. and Heng, P. W. S. (2011) In Vitro Dissolution of Pharmaceutical Solids, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch4

Editor Information

  1. 3

    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA

  2. 4

    Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA

Author Information

  1. 1

    Pfizer Global Research and Development, UK

  2. 2

    Department of Pharmacy, National University of Singapore, Singapore

Publication History

  1. Published Online: 5 JUL 2011
  2. Published Print: 15 AUG 2011

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470260999

Online ISBN: 9781118067598

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Keywords:

  • pharmaceutical solids' in vitro dissolution - active pharmaceutical ingredient (API), rate-limiting step;
  • in vitroin vivo correlation (IVIVC) - rational relationship, biological outcome or fate;
  • automated sampling - automation, good quality control of dissolution data

Summary

This chapter contains sections titled:

  • Introduction

  • Factors influencing dissolution

  • Techniques to improve dissolution

  • Dissolution methods and biorelevant media

  • Recent advancements in dissolution testing and prediction

  • Conclusions

  • Additional reading

  • References