9. Efflux of Drugs via Transporters—The Antiabsorption Pathway
- Ming Hu2,
- Xiaoling Li3
Published Online: 5 JUL 2011
DOI: 10.1002/9781118067598.ch9
Copyright © 2011 John Wiley & Sons, Inc.
Book Title
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
Additional Information
How to Cite
Chang, J. H., Uchizono, J. A. and Park, M. S. (2011) Efflux of Drugs via Transporters—The Antiabsorption Pathway, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications (eds M. Hu and X. Li), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118067598.ch9
Editor Information
- 2
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA
- 3
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA
Publication History
- Published Online: 5 JUL 2011
- Published Print: 15 AUG 2011
ISBN Information
Print ISBN: 9780470260999
Online ISBN: 9781118067598
- Summary
- Chapter
- References
Keywords:
- drug efflux via transporters—antiabsorption pathway - pharmacokinetics, oral delivery control rate;
- ABC transporter regulation, multidrug resistance - modulating ABC transporter activities;
- clinical implications, efflux transporters and drug interactions - influencing three pathways
Summary
This chapter contains sections titled:
Introduction
“Antiabsorptive” properties of efflux transporters
ABC transporter superfamily
Regulation of ABC transporters
Clinical implications of efflux transporters and drug interactions
Conclusions and perspectives
References