20. Immunogenicity of Microbial Digestive Enzymes for Oral Replacement Therapy in Pancreatic Exocrine Insufficiency

  1. Michael G. Tovey
  1. Claudia Berger and
  2. Uwe Niesner

Published Online: 20 JUN 2011

DOI: 10.1002/9781118075685.ch20

Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations

Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations

How to Cite

Berger, C. and Niesner, U. (2011) Immunogenicity of Microbial Digestive Enzymes for Oral Replacement Therapy in Pancreatic Exocrine Insufficiency, in Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations (ed M. G. Tovey), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118075685.ch20

Editor Information

  1. Laboratory of Biotechnology and Applied Pharmacology, UMR 8113 ENS-CNRS, Ecole Normale Supérieure de Cachan, 94235 Cachan Cedex, France

Author Information

  1. Abbott Products GmbH, 30173 Hannover, Germany

Publication History

  1. Published Online: 20 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9780470566664

Online ISBN: 9781118075685

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Keywords:

  • microbial digestive enzyme immunogenicity - oral replacement therapy, in pancreatic exocrine insufficiency (PEI);
  • gastrointestinal tract mucosal surface, selective permeability - barrier against microorganisms;
  • immunoglobulin E-mediated hypersensitivity - adverse reaction, ingested harmless proteins

Summary

This chapter contains sections titled:

  • Introduction

  • Pancreatic Exocrine Insufficiency

  • Oral Enzyme Replacement Therapy

  • Absorption of Macromolecules in the Gastrointestinal Tract

  • Physiological Mucosal Immune Responses

  • Allergy and Immunoglobulin E

  • Probability and Consequences of Anti-Drug Antibodies to Microbial Digestive Enzymes

  • Assay Strategy

  • Conclusion

  • References