5. Stress Effects on the Brain

Intracellular Signaling Cascades, Epigenetic Mechanisms, and Implications for Behavior

  1. Cheryl D. Conrad
  1. Johannes M. H. M. Reul,
  2. Andrew Collins and
  3. María Gutièrrez-Mecinas

Published Online: 14 OCT 2011

DOI: 10.1002/9781118083222.ch5

The Handbook of Stress: Neuropsychological Effects on the Brain

The Handbook of Stress: Neuropsychological Effects on the Brain

How to Cite

Reul, J. M. H. M., Collins, A. and Gutièrrez-Mecinas, M. (2011) Stress Effects on the Brain, in The Handbook of Stress: Neuropsychological Effects on the Brain (ed C. D. Conrad), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118083222.ch5

Editor Information

  1. Department of Psychology and Division of Natural Sciences, College of Liberal Arts and Sciences, Arizona State University, USA

Author Information

  1. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK

Publication History

  1. Published Online: 14 OCT 2011
  2. Published Print: 11 AUG 2011

Book Series:

  1. Wiley-Blackwell Handbooks of Behavioral Neuroscience

Book Series Editors:

  1. David Mostofsky

Series Editor Information

  1. Boston University, USA

ISBN Information

Print ISBN: 9781444330236

Online ISBN: 9781118083222



  • intracellular signaling cascades and behavior;
  • autonomic and neuroendocrine changes;
  • stress and cognition;
  • forced-swim test or Porsolt forced-swim test;
  • neurotransmitters and epigenetic mechanisms;
  • NMDA receptor-mediated signaling and neuroplasticity;
  • gene transcription and epigenetic mechanism control;
  • dentate gyrus, as part of hippocampus;
  • Morris water-maze learning;
  • NMDA/ERK MAPK signaling pathway


This chapter contains sections titled:

  • Introduction

  • The Inter-relationship of Stress and Cognition

  • NMDA Receptor-mediated Signaling and Neuroplasticity

  • Epigenetic Mechanisms in Gene Transcription

  • Emotional Challenges Result in Transcription- r elated Histone Modifi cations in the Brain

  • The Dentate Gyrus Shows Sparse Epigenetic Responses

  • Integration of Extracellular and Intracellular Pathways Signaling to the Chromatin

  • Significance of H3S10p/K14ac-associated Gene Expression in Dentate Gyrus Granule Neurons in Hippocampus-related Memory Formation

  • Concluding Remarks

  • References