5. Kinetic Mechanism of Inhibition of One-Substrate Enzymatic Reactions

  1. Ross L. Stein

Published Online: 27 MAY 2011

DOI: 10.1002/9781118084410.ch5

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

How to Cite

Stein, R. L. (2011) Kinetic Mechanism of Inhibition of One-Substrate Enzymatic Reactions, in Kinetics of Enzyme Action: Essential Principles for Drug Hunters, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118084410.ch5

Publication History

  1. Published Online: 27 MAY 2011
  2. Published Print: 25 JUL 2011

ISBN Information

Print ISBN: 9780470414118

Online ISBN: 9781118084410

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Keywords:

  • kinetic mechanism of inhibition - of one-substrate enzymatic reactions;
  • initial velocity data analysis - for enzyme inhibition;
  • one-substrate, two-intermediate reaction inhibition

Summary

This chapter contains sections titled:

  • Importance in Drug Discovery

  • Theoretical Considerations

  • Analysis of Initial Velocity Data for Enzyme Inhibition

  • Inhibition of One-Substrate, Two-Intermediate Reactions

  • Inhibition by Depletion of Substrate