6. Tight-Binding, Slow-Binding, and Irreversible Inhibition

  1. Ross L. Stein

Published Online: 27 MAY 2011

DOI: 10.1002/9781118084410.ch6

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

How to Cite

Stein, R. L. (2011) Tight-Binding, Slow-Binding, and Irreversible Inhibition, in Kinetics of Enzyme Action: Essential Principles for Drug Hunters, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118084410.ch6

Publication History

  1. Published Online: 27 MAY 2011
  2. Published Print: 25 JUL 2011

ISBN Information

Print ISBN: 9780470414118

Online ISBN: 9781118084410

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Keywords:

  • tight-binding, slow-binding, and irreversible inhibition - inhibitor potency, drug discovery program;
  • slow-binding inhibition - and “slow-binding inhibitors,” full inhibitory potency, not immediate;
  • irreversible inhibition, and irreversible inhibitors - binding to active site of target enzymes

Summary

This chapter contains sections titled:

  • Importance in Drug Discovery

  • Tight-Binding Inhibition

  • Slow-Binding Inhibition

  • Irreversible Inhibition