8. Kinetic Mechanism of Inhibition of Two-Substrate Enzymatic Reactions

  1. Ross L. Stein

Published Online: 27 MAY 2011

DOI: 10.1002/9781118084410.ch8

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

Kinetics of Enzyme Action: Essential Principles for Drug Hunters

How to Cite

Stein, R. L. (2011) Kinetic Mechanism of Inhibition of Two-Substrate Enzymatic Reactions, in Kinetics of Enzyme Action: Essential Principles for Drug Hunters, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118084410.ch8

Publication History

  1. Published Online: 27 MAY 2011
  2. Published Print: 25 JUL 2011

ISBN Information

Print ISBN: 9780470414118

Online ISBN: 9781118084410

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Keywords:

  • kinetic mechanism of inhibition - of two-substrate enzymatic reactions;
  • success, medicinal chemical optimization programs - inhibition of two-substrate reaction kinetics;
  • substrate analog inhibition - inhibitor, binding to targeted enzyme in same manner as substrate

Summary

This chapter contains sections titled:

  • Importance in Drug Discovery

  • Mechanisms of Inhibition of Two-Substrate Reactions

  • Inhibition by Substrate Analogs

  • Analysis of Sequential Reactions in which Inhibitor Binds to Enzyme : Product Complexes

  • Driving SAR Programs for Two-Substrate Enzymatic Reactions