5. Multicopper Proteins

  1. Kenneth D. Karlin2 and
  2. Shinobu Itoh3
  1. Takeshi Sakurai and
  2. Kunishige Kataoka

Published Online: 11 AUG 2011

DOI: 10.1002/9781118094365.ch5

Copper-Oxygen Chemistry

Copper-Oxygen Chemistry

How to Cite

Sakurai, T. and Kataoka, K. (2011) Multicopper Proteins, in Copper-Oxygen Chemistry (eds K. D. Karlin and S. Itoh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118094365.ch5

Editor Information

  1. 2

    Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA

  2. 3

    Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan

Author Information

  1. Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan

Publication History

  1. Published Online: 11 AUG 2011
  2. Published Print: 16 SEP 2011

ISBN Information

Print ISBN: 9780470528358

Online ISBN: 9781118094365



  • multicopper proteins to multicopper oxidase (MCO) - type I copper, type II copper and pair of type III coppers;
  • substrate binding and specificity - MCOs, redox potential, more negative than that of T1;
  • modification of multicopper oxidases - mutation, oxidizing activities toward organic substances


This chapter contains sections titled:

  • Introduction

  • Molecular architecture of multicopper oxidases

  • Structure of the copper-binding centers

  • Spectral properties

  • Substrate binding and specificity

  • Four-electron reduction of dioxygen by multicopper oxidases

  • Modification of multicopper oxidases

  • Conclusions and future prospects

  • Acknowledgments

  • Abbreviations

  • References