15. Multicomponent Therapeutics

  1. Jens-Uwe Peters
  1. Alexis A. Borisy1,
  2. Grant R. Zimmermann2 and
  3. Joseph Lehár3

Published Online: 28 FEB 2012

DOI: 10.1002/9781118098141.ch15

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery

How to Cite

Borisy, A. A., Zimmermann, G. R. and Lehár, J. (2012) Multicomponent Therapeutics, in Polypharmacology in Drug Discovery (ed J.-U. Peters), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118098141.ch15

Editor Information

  1. F. Hoffmann-LaRoche Ltd., Pharmaceuticals Division, Discovery Chemistry, Building/Room 92/3.64C, CH-4070 Basel, Switzerland

Author Information

  1. 1

    Third Rock Ventures, 29 Newbury Street, Boston, MA 02116, USA

  2. 2

    Zalicus Incorporated, 245 First Street, Cambridge, MA 02142, USA

  3. 3

    Department of Bioinformatics, Boston University, 44 Cummington Street, Boston, MA 02215, USA

Publication History

  1. Published Online: 28 FEB 2012
  2. Published Print: 17 FEB 2012

ISBN Information

Print ISBN: 9780470590904

Online ISBN: 9781118098141

SEARCH

Keywords:

  • multicomponent therapeutics, context-dependent;
  • synergistic, antiinflammatory and therapeutic selectivity;
  • synergistic therapies

Summary

This chapter contains sections titled:

  • Introduction

  • Why Drug Synergies are Statistically More Context-Dependent

  • How a Synergistic Mechanism Can Lead to Therapeutic Selectivity

  • Discussion

  • References