15. Mass Spectrometry for the Study of Peptide Drug Metabolism

  1. Michael L. Gross2,
  2. Guodong Chen3 and
  3. Birendra N. Pramanik4
  1. Patrick J. Rudewicz

Published Online: 23 SEP 2011

DOI: 10.1002/9781118116555.ch15

Protein and Peptide Mass Spectrometry in Drug Discovery

Protein and Peptide Mass Spectrometry in Drug Discovery

How to Cite

Rudewicz, P. J. (2011) Mass Spectrometry for the Study of Peptide Drug Metabolism, in Protein and Peptide Mass Spectrometry in Drug Discovery (eds M. L. Gross, G. Chen and B. N. Pramanik), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118116555.ch15

Editor Information

  1. 2

    Washington University, St. Louis, MO, USA

  2. 3

    Bristol-Myers Squibb, Princeton, NJ, USA

  3. 4

    Merck Research Laboratories, Kenilworth, NJ, USA

Author Information

  1. Elan Pharmaceuticals, South San Francisco, CA, USA

Publication History

  1. Published Online: 23 SEP 2011
  2. Published Print: 21 OCT 2011

ISBN Information

Print ISBN: 9780470258170

Online ISBN: 9781118116555

SEARCH

Keywords:

  • peptide drug metabolism;
  • quantitation SRM mode;
  • protein, antibody drug quantitative analysis

Summary

This chapter contains sections titled:

  • Introduction

  • Peptide Drug Metabolism

  • LC-MS/MS for Metabolite Identification

  • Quantitative Analysis

  • Case Study: IL-1β Protease Inhibitors

  • Future Directions

  • References