3. Target Proteins: Bottom-Up and Top-Down Proteomics

  1. Michael L. Gross1,
  2. Guodong Chen2 and
  3. Birendra N. Pramanik3
  1. Michael Boyne and
  2. Ron Bose

Published Online: 23 SEP 2011

DOI: 10.1002/9781118116555.ch3

Protein and Peptide Mass Spectrometry in Drug Discovery

Protein and Peptide Mass Spectrometry in Drug Discovery

How to Cite

Boyne, M. and Bose, R. (2011) Target Proteins: Bottom-Up and Top-Down Proteomics, in Protein and Peptide Mass Spectrometry in Drug Discovery (eds M. L. Gross, G. Chen and B. N. Pramanik), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118116555.ch3

Editor Information

  1. 1

    Washington University, St. Louis, MO, USA

  2. 2

    Bristol-Myers Squibb, Princeton, NJ, USA

  3. 3

    Merck Research Laboratories, Kenilworth, NJ, USA

Author Information

  1. Washington University, St. Louis, MO, USA

Publication History

  1. Published Online: 23 SEP 2011
  2. Published Print: 21 OCT 2011

ISBN Information

Print ISBN: 9780470258170

Online ISBN: 9781118116555

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Keywords:

  • targeted protein identification;
  • bottom-up, top-down proteomics;
  • GeLC-MS/MS approaches

Summary

This chapter contains sections titled:

  • Mass Spectral Approaches to Targeted Protein Identification

  • Bottom-up Proteomics

  • Top-down Approaches

  • Next-Generation Approaches

  • References