9. Bioinformatics and Database Searching

  1. Michael L. Gross2,
  2. Guodong Chen3 and
  3. Birendra N. Pramanik4
  1. Surendra Dasari and
  2. David L. Tabb

Published Online: 23 SEP 2011

DOI: 10.1002/9781118116555.ch9

Protein and Peptide Mass Spectrometry in Drug Discovery

Protein and Peptide Mass Spectrometry in Drug Discovery

How to Cite

Dasari, S. and Tabb, D. L. (2011) Bioinformatics and Database Searching, in Protein and Peptide Mass Spectrometry in Drug Discovery (eds M. L. Gross, G. Chen and B. N. Pramanik), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118116555.ch9

Editor Information

  1. 2

    Washington University, St. Louis, MO, USA

  2. 3

    Bristol-Myers Squibb, Princeton, NJ, USA

  3. 4

    Merck Research Laboratories, Kenilworth, NJ, USA

Author Information

  1. Vanderbilt University Medical Center, Nashville, TN, USA

Publication History

  1. Published Online: 23 SEP 2011
  2. Published Print: 21 OCT 2011

ISBN Information

Print ISBN: 9780470258170

Online ISBN: 9781118116555

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Keywords:

  • bioinformatics, IDPicker software;
  • shotgun proteomics;
  • MyriMatch database search engine

Summary

This chapter contains sections titled:

  • Overview

  • Introduction to Tandem Mass Spectrometry

  • Overview of Peptide Identification with Database Searching

  • MyriMatch-IDPicker Protein Identification Pipeline

  • Results of a Shotgun Proteomics Study

  • Improvements to MyriMatch Database Search Engine

  • Applications of MyriMatch-IDPicker Pipeline

  • Conclusions

  • Acknowledgments

  • References