25. Electronic Circular Dichroism in Drug Discovery

  1. Nina Berova2,
  2. Prasad L. Polavarapu3,
  3. Koji Nakanishi2 and
  4. Robert W. Woody4
  1. Carlo Bertucci and
  2. Marco Pistolozzi

Published Online: 17 FEB 2012

DOI: 10.1002/9781118120392.ch25

Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules, Volume 2

Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules, Volume 2

How to Cite

Bertucci, C. and Pistolozzi, M. (2012) Electronic Circular Dichroism in Drug Discovery, in Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules, Volume 2 (eds N. Berova, P. L. Polavarapu, K. Nakanishi and R. W. Woody), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118120392.ch25

Editor Information

  1. 2

    Department of Chemistry, Columbia University, New York, New York, USA

  2. 3

    Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA

  3. 4

    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA

Author Information

  1. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

Publication History

  1. Published Online: 17 FEB 2012
  2. Published Print: 24 FEB 2012

ISBN Information

Print ISBN: 9781118012925

Online ISBN: 9781118120392

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Keywords:

  • ECD in drug discovery;
  • CD spectra changes, protein transitions;
  • interactome, molecular recognition phenomena

Summary

This chapter contains sections titled:

  • Protein–Ligand Interactions

  • Conformational Transitions of Peptides and Proteins

  • CD in the Analysis of Recombinant Protein Therapeutics

  • Conclusions and Perspectives

  • References