4. The Evolution of Cell–Cell Communication

  1. John S. Torday and
  2. Virender K. Rehan

Published Online: 14 MAR 2012

DOI: 10.1002/9781118130452.ch4

Evolutionary Biology, Cell-Cell Communication, and Complex Disease

Evolutionary Biology, Cell-Cell Communication, and Complex Disease

How to Cite

Torday, J. S. and Rehan, V. K. (2012) The Evolution of Cell–Cell Communication, in Evolutionary Biology, Cell-Cell Communication, and Complex Disease, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118130452.ch4

Author Information

  1. Harbor–UCLA Medical Center, David Geffen School of Medicine, University of California[BOND]Los Angeles, USA

Publication History

  1. Published Online: 14 MAR 2012
  2. Published Print: 2 FEB 2012

ISBN Information

Print ISBN: 9780470647202

Online ISBN: 9781118130452



  • cell–cell communication evolution;
  • cell–cell communication, metazoan evolution;
  • androgen and growth factor expression


This chapter contains sections titled:

  • Cell–Cell Communication as the Mechanistic Basis for Evolutionary Biology

  • The Darwinian Biologic Spacetime Continuum and Einstein's Vision of the Universe

  • Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution

  • Cell–Cell Communication as the Basis for the Evolution of Metazoans

  • Understanding Lung Evolution from the Middle Out

  • The Cell–Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes

  • Predictive Value of the Lung Cell–Cell Communication Model for Understanding the Evolution of Physiologic Systems

  • Sexual Dimorphism of Lung Development: A Case Study in Cell–Cell Communication and Evolutionary Plasticity

  • Androgen Affects the Expression of Growth Factors Involved in Lung Development

  • Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes