5. Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO)

  1. Peter J. H. Scott and
  2. Brian G. Hockley
  1. Patrick J. Riss,
  2. Valentina Ferrari,
  3. Robert Bielik,
  4. Roberto Canales-Candela,
  5. Rob Smith and
  6. Franklin I. Aigbirhio

Published Online: 4 JAN 2012

DOI: 10.1002/9781118140345.ch5

Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1

Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1

How to Cite

Riss, P. J., Ferrari, V., Bielik, R., Canales-Candela, R., Smith, R. and Aigbirhio, F. I. (2012) Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO), in Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1 (eds P. J. H. Scott and B. G. Hockley), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118140345.ch5

Editor Information

  1. Department of Radiology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

Author Information

  1. Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

Publication History

  1. Published Online: 4 JAN 2012
  2. Published Print: 13 JAN 2012

ISBN Information

Print ISBN: 9780470588956

Online ISBN: 9781118140345

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Keywords:

  • synthesis of [18F]fluoromisonidazole, nitroimidazole for PET;
  • [18F]fluoride label, via aliphatic nucleophilic substitution of leaving group;
  • quality control of [18F]FMISO, release criteria

Summary

This chapter contains sections titled:

  • Introduction

  • Synthesis Procedure

  • Quality Control (QC) Procedures

  • Chemical Abstracts Nomenclature (Registry Number)

  • References and Notes