5. Design and Analysis of Randomized Clinical Trials

  1. Klaus Hinkelmann
  1. Janet Wittes1 and
  2. Zi-Fan Yu2

Published Online: 3 JAN 2012

DOI: 10.1002/9781118147634.ch5

Design and Analysis of Experiments: Special Designs and Applications, Volume 3

Design and Analysis of Experiments: Special Designs and Applications, Volume 3

How to Cite

Wittes, J. and Yu, Z.-F. (2012) Design and Analysis of Randomized Clinical Trials, in Design and Analysis of Experiments: Special Designs and Applications, Volume 3 (ed K. Hinkelmann), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118147634.ch5

Editor Information

  1. Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

Author Information

  1. 1

    Blood Institute, Bethesda, Maryland, USA

  2. 2

    Statistics Collaborative, Inc., Washington, DC, USA

Publication History

  1. Published Online: 3 JAN 2012
  2. Published Print: 27 JAN 2012

Book Series:

  1. Wiley Series in Probability and Statistics

Book Series Editors:

  1. David J. Balding,
  2. Noel A. C. Cressie,
  3. Garrett M. Fitzmaurice,
  4. Harvey Goldstein,
  5. Iain M. Johnstone,
  6. Geert Molenberghs,
  7. David W. Scott,
  8. Adrian F. M. Smith,
  9. Ruey S. Tsay and
  10. Sanford Weisberg

ISBN Information

Print ISBN: 9780470530689

Online ISBN: 9781118147634

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Keywords:

  • randomized clinical trials, and statistical analysis;
  • confirmatory or phase 3 trials, bias, variability and masking;
  • failure time studies, and survival time

Summary

This chapter contains sections titled:

  • Overview

  • Components of a Randomized Clinical Trial

  • Bias

  • Statistical Analysis of Randomized Clinical Trials

  • Failure Time Studies

  • Other Topics

  • References