24. The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress

  1. Tahira Farooqui3 and
  2. Akhlaq A. Farooqui4
  1. Jun Hee Lee1 and
  2. Ethan Bier2

Published Online: 7 NOV 2011

DOI: 10.1002/9781118148143.ch24

Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling

Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling

How to Cite

Hee Lee, J. and Bier, E. (2011) The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress, in Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118148143.ch24

Editor Information

  1. 3

    Department of Entomology/Center of Molecular Neurobiology, The Ohio State University, Columbus, Ohio, USA

  2. 4

    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, USA

Author Information

  1. 1

    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

  2. 2

    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA

Publication History

  1. Published Online: 7 NOV 2011
  2. Published Print: 18 NOV 2011

ISBN Information

Print ISBN: 9781118001943

Online ISBN: 9781118148143

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Keywords:

  • sestrins, and chronic TOR;
  • oxidative stress, oxidative respiration;
  • chronic TORC1 stress-associated

Summary

This chapter contains sections titled:

  • Introduction

  • Sestrin-A Unique Gene Family

  • Regulation of Sestrin Expression by Stresses

  • Sestrin as a Redox Regulator

  • Overview of TORC1 Signaling

  • Chronic TORC1 Induces Stress-Associated Pathologies

  • Sestrin as a Suppressor of TORC1

  • Sestrin Deficiency Results in Age-Associated Pathologies

  • Conclusion and Perspectives

  • References