5. Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance

  1. Patricia L. Keen2 and
  2. Mark H. M. M. Montforts3
  1. Lucia Fernandez,
  2. Elena B. M. Breidenstein and
  3. Robert E. W. Hancock

Published Online: 7 DEC 2011

DOI: 10.1002/9781118156247.ch5

Antimicrobial Resistance in the Environment

Antimicrobial Resistance in the Environment

How to Cite

Fernandez, L., Breidenstein, E. B. M. and Hancock, R. E. W. (2011) Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance, in Antimicrobial Resistance in the Environment (eds P. L. Keen and M. H. M. M. Montforts), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118156247.ch5

Editor Information

  1. 2

    Faculty of Applied Science, University of British Columbia, Vancouver, British Columbia, Canada

  2. 3

    National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Author Information

  1. Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

Publication History

  1. Published Online: 7 DEC 2011
  2. Published Print: 30 DEC 2011

ISBN Information

Print ISBN: 9780470905425

Online ISBN: 9781118156247

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Keywords:

  • antimicrobial resistance, adaptive, stepwise changes;
  • intrinsic resistome and mutational resistome;
  • adaptive resistance triggers, and resistance phenotype

Summary

This chapter contains sections titled:

  • Introduction

  • Transcriptional Responses to Antimicrobials

  • Stepwise Increase in Resistance (Intrinsic Resistome and Mutational Resistome)

  • Mechanisms of Adaptive Resistance

  • Conclusion

  • Acknowledgments

  • References