12. Accelerator Mass Spectrometry in Pharmaceutical Development

  1. Mike S. Lee
  1. Benjamin J. Stewart1,
  2. Graham Bench1,
  3. Bruce A. Buchholz1,
  4. Kurt W. Haack2,
  5. Michael A. Malfatti2,
  6. Ted J. Ognibene1 and
  7. Kenneth W. Turteltaub2

Published Online: 21 MAY 2012

DOI: 10.1002/9781118180730.ch12

Mass Spectrometry Handbook

Mass Spectrometry Handbook

How to Cite

Stewart, B. J., Bench, G., Buchholz, B. A., Haack, K. W., Malfatti, M. A., Ognibene, T. J. and Turteltaub, K. W. (2012) Accelerator Mass Spectrometry in Pharmaceutical Development, in Mass Spectrometry Handbook (ed M. S. Lee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118180730.ch12

Editor Information

  1. Milestone Development Services, USA

Author Information

  1. 1

    Lawrence Livermore National Laboratory, Center for Accelerator Mass Spectrometry, Livermore, CA, USA

  2. 2

    Lawrence Livermore National Laboratory, Biosciences and Biotechnology Division, Livermore, CA, USA

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, USA

ISBN Information

Print ISBN: 9780470536735

Online ISBN: 9781118180730

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Keywords:

  • AMS in pharmaceutical development;
  • AMS in biological sciences, of dosed tissue concentrations;
  • AMS in drug development, biological AMS designed to individual basis;
  • investigational compounds and AMS applications

Summary

This chapter contains sections titled:

  • Introduction to Biological Accelerator Mass Spectrometry

  • Applications of AMS in Drug Development

  • Example Calculation of Dosed Tissue Concentration

  • Summary

  • References