5. Preclinical Pharmacokinetics: Industrial Perspective

  1. Mike S. Lee
  1. Ayman El-Kattan and
  2. Manthena Varma

Published Online: 21 MAY 2012

DOI: 10.1002/9781118180730.ch5

Mass Spectrometry Handbook

Mass Spectrometry Handbook

How to Cite

El-Kattan, A. and Varma, M. (2012) Preclinical Pharmacokinetics: Industrial Perspective, in Mass Spectrometry Handbook (ed M. S. Lee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118180730.ch5

Editor Information

  1. Milestone Development Services, USA

Author Information

  1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, CT, USA

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, USA

ISBN Information

Print ISBN: 9780470536735

Online ISBN: 9781118180730



  • preclinical pharmacokinetics, an industrial perspective;
  • LC/MS/MS, novel drugs, and quantitative measurement;
  • LC/MS/MS in bioanalytical needs, in NCE assessment;
  • pharmacokinetic studies, in-life phase, bioanalysis, data analysis;
  • novel study designs, N-in-One dosing/analysis and limited sample time


This chapter contains sections titled:

  • Introduction

  • A Pharmacokinetics Primer

  • Parameters that Define Pharmacokinetic Profile

  • Modeling to Predict Single- and Multiple-Dose Pharmacokinetic Profiles

  • Role of LC/MS/MS in Pharmacokinetic Assessment in Drug Discovery

  • References