6. LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective

  1. Mike S. Lee
  1. Wenying Jian1,
  2. Wilson Shou2,
  3. Richard W. Edom1,
  4. Naidong Weng1 and
  5. Mingshe Zhu3

Published Online: 21 MAY 2012

DOI: 10.1002/9781118180730.ch6

Mass Spectrometry Handbook

Mass Spectrometry Handbook

How to Cite

Jian, W., Shou, W., Edom, R. W., Weng, N. and Zhu, M. (2012) LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective, in Mass Spectrometry Handbook (ed M. S. Lee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118180730.ch6

Editor Information

  1. Milestone Development Services, USA

Author Information

  1. 1

    Janssen Research & Development, Raritan, NJ, USA

  2. 2

    Applied Biotechnology, Bristol-Myers Squibb, Wallingford, CT, USA

  3. 3

    Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, NJ, USA

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, USA

ISBN Information

Print ISBN: 9780470536735

Online ISBN: 9781118180730

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Keywords:

  • LC-MS in drug metabolism, from a pharmaceutical perspective;
  • LC-MS for in vitro ADME screening in drug discovery;
  • ADME, vendor software with a company's informatics infrastructure;
  • LC-MS in drug metabolite profiling, identification;
  • drug metabolite identification, a key component of DMPK

Summary

This chapter contains sections titled:

  • Introduction

  • Instrumentation Utilized for DMPK Studies

  • LC-MS for in Vitro ADME Screening

  • LC-MS for in Vivo Bioanalysis in Support of DMPK

  • LC-MS in Drug Metabolite Profiling and Identification

  • Summary and Perspective

  • Acknowledgments

  • References