7. Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies

  1. Mike S. Lee
  1. Xiaoying Xu1 and
  2. Wenkui Li2

Published Online: 21 MAY 2012

DOI: 10.1002/9781118180730.ch7

Mass Spectrometry Handbook

Mass Spectrometry Handbook

How to Cite

Xu, X. and Li, W. (2012) Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies, in Mass Spectrometry Handbook (ed M. S. Lee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118180730.ch7

Editor Information

  1. Milestone Development Services, USA

Author Information

  1. 1

    China Novartis Institute for BioMedical Research Co., Ltd., Shanghai Pudong Software Park, Zhangjiang Hi-Tech Park, Pudong, China

  2. 2

    Novartis Pharmaceuticals Corporation, Drug Metabolism & Bioanalytics, East Hanover, NJ, USA

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, USA

ISBN Information

Print ISBN: 9780470536735

Online ISBN: 9781118180730

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Keywords:

  • quantitative MS, supporting pharmacokinetic studies;
  • PK properties, decision-making criteria in drug candidate selection;
  • LC-MS/MS tool of choice, with QqQ for quantitative analysis;
  • stepwise laboratory protocol and methods, unknown sample analysis;
  • LC-MS/MS bioanalytical method, matrix effects and stability

Summary

This chapter contains sections titled:

  • Introduction

  • Methodology

  • Current Protocol

  • Definitions

  • References