8. Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS

  1. Mike S. Lee
  1. Margrét Thorsteinsdóttir1,
  2. Baldur Bragi Sigurðsson2 and
  3. Gísli Bragason2

Published Online: 21 MAY 2012

DOI: 10.1002/9781118180730.ch8

Mass Spectrometry Handbook

Mass Spectrometry Handbook

How to Cite

Thorsteinsdóttir, M., Sigurðsson, B. B. and Bragason, G. (2012) Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS, in Mass Spectrometry Handbook (ed M. S. Lee), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118180730.ch8

Editor Information

  1. Milestone Development Services, USA

Author Information

  1. 1

    Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Reykjavik, Iceland

  2. 2

    ArcticMass, Sturlugata, Reykjavik, Iceland

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, USA

ISBN Information

Print ISBN: 9780470536735

Online ISBN: 9781118180730

SEARCH

Keywords:

  • HPLC-MS/MS in drug PK parameter determination, and UPLC-MS/MS;
  • HPLC-MS/MS, compounds analyzed simultaneously;
  • workflow for PK determination with LC-MS/MS;
  • PK assays for drug candidate in clinicals;
  • PK, early in drug discovery, validation after DoE optimization

Summary

This chapter contains sections titled:

  • Introduction

  • LC-MS/MS Assays for PK Determination in Drug Discovery

  • PK Evaluation of Lead Candidate and Metabolites in Preclinical Development

  • PK Assays for Drug Candidate during Clinical Development

  • Conclusion

  • References