4. Phase I Trial Design

  1. Guosheng Yin

Published Online: 9 JAN 2012

DOI: 10.1002/9781118183335.ch4

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

How to Cite

Yin, G. (2011) Phase I Trial Design, in Clinical Trial Design: Bayesian and Frequentist Adaptive Methods, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118183335.ch4

Publication History

  1. Published Online: 9 JAN 2012
  2. Published Print: 19 DEC 2011

ISBN Information

Print ISBN: 9780470581711

Online ISBN: 9781118183335

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Keywords:

  • continual reassessment method;
  • probability model;
  • dose-finding algorithm;
  • Bayesian model;
  • sensitivity analysis

Summary

This chapter contains sections titled:

  • Maximum Tolerated Dose

  • Initial Dose and Spacing

  • 3 + 3 Design

  • A + B Design

  • Accelerated Titration Design

  • Biased Coin Dose-Finding Method

  • Continual Reassessment Method

  • Bayesian Model Averaging Continual Reassessment Method

  • Escalation with Overdose Control

  • Bayesian Hybrid Design

  • Summary