5. Phase II Trial Design

  1. Guosheng Yin

Published Online: 9 JAN 2012

DOI: 10.1002/9781118183335.ch5

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

How to Cite

Yin, G. (2011) Phase II Trial Design, in Clinical Trial Design: Bayesian and Frequentist Adaptive Methods, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118183335.ch5

Publication History

  1. Published Online: 9 JAN 2012
  2. Published Print: 19 DEC 2011

ISBN Information

Print ISBN: 9780470581711

Online ISBN: 9781118183335

SEARCH

Keywords:

  • two-stage design;
  • Bayesian phase;
  • posterior probability;
  • predictive probability;
  • parameter calibration

Summary

This chapter contains sections titled:

  • Gehan's Two-Stage Design

  • Simon's Two-Stage Design

  • Bayesian Phase II Design with Posterior Probability

  • Bayesian Phase II Design with Predictive Probability

  • Predictive Monitoring in Randomized Phase II Trials

  • Predictive Probability with Adaptive Randomization

  • Bayesian Phase II Design with Multiple Outcomes

  • Phase I/II Design with Bivariate Binary Data

  • Phase I/II Design with Times to Toxicity and Efficacy

  • Summary