7. Adaptive Randomization

  1. Guosheng Yin

Published Online: 9 JAN 2012

DOI: 10.1002/9781118183335.ch7

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

How to Cite

Yin, G. (2011) Adaptive Randomization, in Clinical Trial Design: Bayesian and Frequentist Adaptive Methods, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118183335.ch7

Publication History

  1. Published Online: 9 JAN 2012
  2. Published Print: 19 DEC 2011

ISBN Information

Print ISBN: 9780470581711

Online ISBN: 9781118183335

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Keywords:

  • adaptive randomization;
  • simple randomization;
  • permuted block randomization;
  • stratified randomization;
  • covariate-adaptive allocation

Summary

This chapter contains sections titled:

  • Introduction

  • Simple Randomization

  • Permuted Block Randomization

  • Stratified Randomization

  • Covariate-Adaptive Allocation by Minimization

  • Biased Coin Design

  • Play-the-Winner Rule

  • Drop-the-Loser Rule

  • Optimal Adaptive Randomization

  • Doubly Adaptive Biased Coin Design

  • Bayesian Adaptive Randomization

  • Adaptive Randomization with Efficacy and Toxicity Trade-offs

  • Fixed or Adaptive Randomization?