9. Drug-Combination Trials

  1. Guosheng Yin

Published Online: 9 JAN 2012

DOI: 10.1002/9781118183335.ch9

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

How to Cite

Yin, G. (2011) Drug-Combination Trials, in Clinical Trial Design: Bayesian and Frequentist Adaptive Methods, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118183335.ch9

Publication History

  1. Published Online: 9 JAN 2012
  2. Published Print: 19 DEC 2011

ISBN Information

Print ISBN: 9780470581711

Online ISBN: 9781118183335

SEARCH

Keywords:

  • sequential dose-finding scheme;
  • copula-type regression;
  • clayton-type model;
  • bivariate binary outcomes;
  • latent contingency table

Summary

This chapter contains sections titled:

  • Why Are Drugs Combined?

  • New Challenges

  • Sequential Dose-Finding Scheme

  • Dose Finding with Copula-Type Regression

  • Latent Contingency Table Approach

  • Phase I/II Drug-Combination Trial

  • Summary