3. Voltage-Gated Sodium Channels as Therapeutic Targets

  1. Luis M. Botana2 and
  2. Mabel Loza3
  1. Joshua S. Wingerd,
  2. Irina Vetter and
  3. Richard J. Lewis

Published Online: 29 MAY 2012

DOI: 10.1002/9781118185537.ch3

Therapeutic Targets: Modulation, Inhibition, and Activation

Therapeutic Targets: Modulation, Inhibition, and Activation

How to Cite

Wingerd, J. S., Vetter, I. and Lewis, R. J. (2012) Voltage-Gated Sodium Channels as Therapeutic Targets, in Therapeutic Targets: Modulation, Inhibition, and Activation (eds L. M. Botana and M. Loza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118185537.ch3

Editor Information

  1. 2

    University of Santiago de Compostela, Spain

  2. 3

    Biofarma Research Group/USEF Screening Platform, Department of Pharmacology, University of Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain

Author Information

  1. Institute for Molecular Biosciences, University of Queensland, Australia

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 4 MAY 2012

ISBN Information

Print ISBN: 9780470587195

Online ISBN: 9781118185537

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Keywords:

  • voltage-gated sodium channels, as therapeutic targets;
  • sodium (Na+) channels, gated pores conducting Na+ into cell types;
  • protein–protein modulation of Nav channels;
  • novel, high-throughput electrophysiology, for novel drug leads;
  • voltage-gated sodium channels, therapeutic targets in diseases

Summary

This chapter contains sections titled:

  • Introduction

  • Introduction to Voltage-Gated Sodium Channels

  • Nav Modulation with Peptides and Small Molecules

  • New Therapeutic Directions for NaV Channel Drug Discovery

  • Conclusions

  • References