4. Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke

  1. Luis M. Botana3 and
  2. Mabel Loza4
  1. Antonio M. G. de Diego1,
  2. Silvia Lorrio1,
  3. Jesús M. Hernández-Guijo1,
  4. Luis Gandía1 and
  5. Antonio G. García1,2

Published Online: 29 MAY 2012

DOI: 10.1002/9781118185537.ch4

Therapeutic Targets: Modulation, Inhibition, and Activation

Therapeutic Targets: Modulation, Inhibition, and Activation

How to Cite

de Diego, A. M. G., Lorrio, S., Hernández-Guijo, J. M., Gandía, L. and García, A. G. (2012) Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke, in Therapeutic Targets: Modulation, Inhibition, and Activation (eds L. M. Botana and M. Loza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118185537.ch4

Editor Information

  1. 3

    University of Santiago de Compostela, Spain

  2. 4

    Biofarma Research Group/USEF Screening Platform, Department of Pharmacology, University of Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain

Author Information

  1. 1

    Instituto Teófilo Hernando and Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo, 4, 28029 Madrid, Spain

  2. 2

    Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa. Diego de León, 62, 28006 Madrid, Spain

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 4 MAY 2012

ISBN Information

Print ISBN: 9780470587195

Online ISBN: 9781118185537

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Keywords:

  • multitarget drugs in calcium cycling, neurodegenerative diseases, stroke;
  • Ca ions, in cell physiology in general, and in neurons;
  • calcium, as a ubiquitous cell messenger;
  • Alzheimer's disease, and calcium dysregulation;
  • mitochondrial Ca2+ overload, mPTP opening with apoptotic activation

Summary

This chapter contains sections titled:

  • Introduction

  • Calcium as a Ubiquitous Cell Messenger

  • Calcium Entry into Cells

  • Intracellular Calcium Movement

  • Efflux of Calcium from Cells

  • Calcium Cycling and Calcium Functions in Neurons

  • Calcium Dysregulation in Alzheimer's Disease

  • Calcium Dysregulation in Amyotrophic Lateral Sclerosis

  • Calcium Dysregulation in Parkinson's Disease

  • Calcium Dysregulation in Huntington's Disease

  • Calcium Dysregulation in Stroke

  • The Concept of Multitarget Drug Ligands Used to Rescue from Death the Vulnerable Neurons of Neurodegenerative Diseases and Stroke

  • Conclusions and Perspectives

  • References