13. Gene Therapy Targeting Kidney Diseases: Routes and Vehicles

  1. Yashwant Pathak2 and
  2. Simon Benita3
  1. Yoshitaka Isaka,
  2. Yoshitsugu Takabatake and
  3. Hiromi Rakugi

Published Online: 23 APR 2012

DOI: 10.1002/9781118229019.ch13

Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

How to Cite

Isaka, Y., Takabatake, Y. and Rakugi, H. (2012) Gene Therapy Targeting Kidney Diseases: Routes and Vehicles, in Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications (eds Y. Pathak and S. Benita), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118229019.ch13

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, USA

  2. 3

    The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

Author Information

  1. Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan

Publication History

  1. Published Online: 23 APR 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9780470612811

Online ISBN: 9781118229019

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Keywords:

  • gene therapy targeting kidney diseases;
  • gene therapy, genetic to target cells and routes;
  • choice of delivery vehicle and administration;
  • NLS, accumulation of plasmid DNA into nucleus;
  • gene transfer targeting, glomeruli, tubule

Summary

This chapter contains sections titled:

  • Introduction

  • Rationale for Successful Gene Targeting

  • Site-Specific Gene Delivery

  • Nuclear Import of Gene Material

  • Targeting the Glomerulus

  • Targeting the Tubule

  • Targeting the Interstitium

  • Targeting Muscle

  • Conclusions

  • References