8. Characterization of Monoclonal Antibody Variants and Glycosylation

  1. Yashwant Pathak2 and
  2. Simon Benita3
  1. Ting Zheng,
  2. Srinivasa Rao,
  3. Jeff Rohrer and
  4. Chris Pohl

Published Online: 23 APR 2012

DOI: 10.1002/9781118229019.ch8

Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

How to Cite

Zheng, T., Rao, S., Rohrer, J. and Pohl, C. (2012) Characterization of Monoclonal Antibody Variants and Glycosylation, in Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications (eds Y. Pathak and S. Benita), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118229019.ch8

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, USA

  2. 3

    The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

Author Information

  1. Thermo Fisher Scientific, Sunnyvale, California, USA

Publication History

  1. Published Online: 23 APR 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9780470612811

Online ISBN: 9781118229019

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Keywords:

  • mAbs variants, characterization and glycosylation;
  • therapeutic proteins and mAbs, transforming biotechnology;
  • mAb heterogeneity characterization by HPLC;
  • mAbs, appropriate glycosylation critical in their efficacy, safety;
  • HPAE–PAD and pre- or postcolumn, absent with MAb N-Glycan

Summary

This chapter contains sections titled:

  • Characterization of Monoclonal Antibody Heterogeneity by HPLC Analysis

  • Analysis of Monoclonal Antibody Glycosylation

  • References