1. The Telomerase Complex: An Overview

  1. Neal F. Lue1 and
  2. Chantal Autexier2,3
  1. Johanna Mancini3 and
  2. Chantal Autexier2,3

Published Online: 21 MAY 2012

DOI: 10.1002/9781118268667.ch1

Telomerases: Chemistry, Biology, and Clinical Applications

Telomerases: Chemistry, Biology, and Clinical Applications

How to Cite

Mancini, J. and Autexier, C. (2012) The Telomerase Complex: An Overview, in Telomerases: Chemistry, Biology, and Clinical Applications (eds N. F. Lue and C. Autexier), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118268667.ch1

Editor Information

  1. 1

    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA

  2. 2

    Departments of Anatomy and Cell Biology, and Medicine, McGill University, Montreal, Quebec, Canada

  3. 3

    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Author Information

  1. 2

    Departments of Anatomy and Cell Biology, and Medicine, McGill University, Montreal, Quebec, Canada

  2. 3

    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 1 JUN 2012

ISBN Information

Print ISBN: 9780470592045

Online ISBN: 9781118268667

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Keywords:

  • telomerase complex, regulation by telomeric proteins, RNAs;
  • telomerase inhibition, alternative telomere maintenance mechanism;
  • telomerase, telomere length in organismal aging, insights into cancer

Summary

This chapter contains sections titled:

  • Conservation of Telomere Function and the Discovery of Telomerase

  • The Discovery of the Two Minimal Telomerase Components

  • Telomerase Beyond the Minimal Components: Associated Proteins

  • Regulation of Telomerase by Telomeric Proteins and RNAS

  • Telomerase, Telomere Maintenance, Cancer, and Aging

  • Telomerase Beyond Telomere Synthesis

  • Telomere Maintenance Without Telomerase

  • Conclusion

  • Acknowledgment

  • References