8. Off-Telomere Functions of Telomerase

  1. Neal F. Lue4 and
  2. Chantal Autexier5,6
  1. Kenkichi Masutomi1 and
  2. William C. Hahn2,3

Published Online: 21 MAY 2012

DOI: 10.1002/9781118268667.ch8

Telomerases: Chemistry, Biology, and Clinical Applications

Telomerases: Chemistry, Biology, and Clinical Applications

How to Cite

Masutomi, K. and Hahn, W. C. (2012) Off-Telomere Functions of Telomerase, in Telomerases: Chemistry, Biology, and Clinical Applications (eds N. F. Lue and C. Autexier), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118268667.ch8

Editor Information

  1. 4

    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA

  2. 5

    Departments of Anatomy and Cell Biology, and Medicine, McGill University, Montreal, Quebec, Canada

  3. 6

    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Author Information

  1. 1

    Cancer Stem Cell Project, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; PREST, Japan Science and Technology Agency, Saitama, Japan

  2. 2

    Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

  3. 3

    Broad Institute of Harvard and MIT, Cambridge, MA, USA

Publication History

  1. Published Online: 21 MAY 2012
  2. Published Print: 1 JUN 2012

ISBN Information

Print ISBN: 9780470592045

Online ISBN: 9781118268667

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Keywords:

  • off-telomere functions, TERT additional functions;
  • nontelomere directed TERT, telomere-dependent, telomere-independent;
  • multiple TERT complexes' role, location, insight into malignancy

Summary

This chapter contains sections titled:

  • Evidence for Nontelomere Directed Tert Functions in Malignant Transformation

  • Evidence for Nontelomere Directed Tert Functions in Stem-Cell Function

  • Multiple Tert Complexes and Biochemical Activities

  • Conclusions

  • References