24. Proteo-Metabolomic Strategies in the Future of Drug Development

  1. Sergio Caroli2 and
  2. Gyula Záray3,4,5
  1. Uwe Christians,
  2. Volker Schmitz,
  3. Jost Klawitter and
  4. Jelena Klawitter

Published Online: 21 JUN 2012

DOI: 10.1002/9781118271858.ch24

Analytical Techniques for Clinical Chemistry: Methods and Applications

Analytical Techniques for Clinical Chemistry: Methods and Applications

How to Cite

Christians, U., Schmitz, V., Klawitter, J. and Klawitter, J. (2012) Proteo-Metabolomic Strategies in the Future of Drug Development, in Analytical Techniques for Clinical Chemistry: Methods and Applications (eds S. Caroli and G. Záray), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118271858.ch24

Editor Information

  1. 2

    National Institute of Health (Istituto Superiore di Sanità), Rome, Italy

  2. 3

    Department of Analytical Chemistry, Eötvös Loránd University, Budapest, Hungary

  3. 4

    Cooperative Research Centre of Environmental Sciences, Eötvös Loránd University, Budapest, Hungary

  4. 5

    Hungarian Satellite Centre of Trace Element for UNESCO, Budapest, Hungary

Author Information

  1. iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Bioscience East, Aurora, CO, USA

Publication History

  1. Published Online: 21 JUN 2012
  2. Published Print: 13 JUL 2012

ISBN Information

Print ISBN: 9780470445273

Online ISBN: 9781118271858

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Keywords:

  • proteo-metabolomic strategies in drug development;
  • detection and monitoring of cell-signal transduction with high detection power;
  • principles of molecular marker development;
  • translating a molecular marker, discovery stage into preclinical testing;
  • protein multiplexing assays, limited by number of suitable antibodies

Summary

This chapter contains sections titled:

  • Summary

  • Introduction

  • The Principles of Molecular Marker Development

  • Technologies for Molecular Marker Development

  • Molecular Markers in Drug Development and Clinical Monitoring

  • Current Challenges

  • References