10. Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities

  1. Yiyun Cheng
  1. Meredith A. Mintzer1,
  2. Olivia M. Merkel2,
  3. Thomas Kissel2 and
  4. Eric E. Simanek3

Published Online: 14 JUN 2012

DOI: 10.1002/9781118275238.ch10

Dendrimer-Based Drug Delivery Systems: From Theory to Practice

Dendrimer-Based Drug Delivery Systems: From Theory to Practice

How to Cite

Mintzer, M. A., Merkel, O. M., Kissel, T. and Simanek, E. E. (2012) Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities, in Dendrimer-Based Drug Delivery Systems: From Theory to Practice (ed Y. Cheng), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118275238.ch10

Editor Information

  1. School of Life Sciences, East China Normal University, P.R. China

Author Information

  1. 1

    Deparments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, USA

  2. 2

    Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Germany

  3. 3

    Department of Chemistry, Texas Christian University, TX, USA

Publication History

  1. Published Online: 14 JUN 2012
  2. Published Print: 15 JUN 2012

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470460054

Online ISBN: 9781118275238

SEARCH

Keywords:

  • triazine dendrimers for DNA and siRNA, challenges and opportunities;
  • DNA or siRNA intravenously, and challenges in finding vectors;
  • nonviral gene carrier efficacy and toxicity, as barrier to nonviral vector use;
  • newest, arginine-modified PAMAM dendrimers, and polymer molecular weight;
  • DNA, triazine dendrimers, cyclic linker groups and transfection

Summary

This chapter contains sections titled:

  • Introduction

  • Triazine Dendrimers: Early Synthetic Achievements

  • Triazine Dendrimers for Transfection: Selection Criteria for Structures

  • DNA Transfection Using Triazine Dendrimers

  • Sirna Transfection Using Triazine Dendrimers

  • Transfection Efficiency of Triazine Dendrimers: DNA Versus Sirna

  • Future Possibilities

  • References