5. Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation

  1. Yiyun Cheng
  1. Mohammad Najlah1,
  2. Zhengyuan Zhou2 and
  3. Antony D'Emanuele2

Published Online: 14 JUN 2012

DOI: 10.1002/9781118275238.ch5

Dendrimer-Based Drug Delivery Systems: From Theory to Practice

Dendrimer-Based Drug Delivery Systems: From Theory to Practice

How to Cite

Najlah, M., Zhou, Z. and D'Emanuele, A. (2012) Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation, in Dendrimer-Based Drug Delivery Systems: From Theory to Practice (ed Y. Cheng), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118275238.ch5

Editor Information

  1. School of Life Sciences, East China Normal University, P.R. China

Author Information

  1. 1

    Faculty of Pharmacy, Albaath University, Syria

  2. 2

    School of Pharmacy and Biomedical Sciences, University of Central Lancashire, UK

Publication History

  1. Published Online: 14 JUN 2012
  2. Published Print: 15 JUN 2012

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470460054

Online ISBN: 9781118275238

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Keywords:

  • dendrimer-based prodrugs, synthesis and biological evaluation;
  • dendrimers, as carrier/delivery, via para- and transcellular pathways;
  • dendrimer-based prodrugs, synthesis and characterization;
  • dendrimer functionality on MTX–PAMAM dendrimer, “one pot” synthetic;
  • dendrimer-based, in vitro stability, cytotoxicity, permeability

Summary

This chapter contains sections titled:

  • Introduction

  • Design of Dendrimer-Based Prodrugs

  • Synthesis and Characterization of Dendrimer-Based Prodrugs

  • In Vitro Stability of Dendrimer-Based Prodrugs

  • In Vitro Cytotoxicity of Dendrimer-Based Prodrugs

  • In Vitro Permeability of Dendrimer-Based Prodrugs

  • Conclusions

  • References