1. Introduction
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch1
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Introduction, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch1
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- bulldozer search for a needle in the haystack;
- multimechanistic processes and Lipinski's “Rule of Five”;
- OIM, intellectual property, distributed and proactively managed;
- ADME, multimechanism screens and Caco-2 permeability;
- “absorption” in ADME, properties related to passive absorption
Summary
This chapter contains sections titled:
Bulldozer Searching for a Needle in the Haystack?
As the Paradigm Turns
Screen for the Target or ADME First?
ADME and Multimechanism Screens
ADME and the Medicinal Chemist
The “Absorption” in ADME
It Is Not Just a Number, It Is a Multimechanism
References