1. Introduction

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch1

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Introduction, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch1

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • bulldozer search for a needle in the haystack;
  • multimechanistic processes and Lipinski's “Rule of Five”;
  • OIM, intellectual property, distributed and proactively managed;
  • ADME, multimechanism screens and Caco-2 permeability;
  • “absorption” in ADME, properties related to passive absorption

Summary

This chapter contains sections titled:

  • Bulldozer Searching for a Needle in the Haystack?

  • As the Paradigm Turns

  • Screen for the Target or ADME First?

  • ADME and Multimechanism Screens

  • ADME and the Medicinal Chemist

  • The “Absorption” in ADME

  • It Is Not Just a Number, It Is a Multimechanism

  • References