2. Transport Model

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch2

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Transport Model, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch2

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • transport model, phospholipid transport by passive diffusion;
  • ionization constants as pH, and Fick's laws of diffusion;
  • BCS, and oral drug absorption effect;
  • permeability control, absorption kinetics and drug biopharmaceuticals;
  • pH microclimate and pH-Partition Hypothesis

Summary

This chapter contains sections titled:

  • Permeability–Solubility–Charge State and pH-Partition Hypothesis

  • Properties of the Gastrointestinal Tract (GIT)

  • pH Microclimate

  • Intracellular pH Environment

  • Tight Junction Complex

  • Structure of Octanol

  • Biopharmaceutics Classification System

  • References