3. pKa Determination
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch3
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) pKa Determination, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch3
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- ionization constant pKa determination by potentiometric technique;
- ionic strength and temperature impact;
- charge state and the pKa, affecting drug absorption;
- constant ionic medium activity scale;
- molality to molarity conversion
Summary
This chapter contains sections titled:
Charge State and the pKa
Methods of Choice for the Determination of the pKa
Titration with a Glass-Membrane pH Electrode
Equilibrium Equations and the Ionization Constant
“Pure Solvent” Activity Scale
Ionic Strength and Debye–Hückel/Davies Equation
“Constant Ionic Medium” Activity Scale
Temperature Dependence of pKa Values
Electrode Calibration and Standardization
Bjerrum Plot: Most Useful Graphical Tool in pKa Analysis
Cosolvent Methods for pKa Determination of Practically Insoluble Substances
Other Methods for pKa Measurement
pKa Microconstants
pKa Compilations
pKa Prediction Programs
Database of pKa (25°C and 37°C)
Quick Start: Determination of the pKa of Codeine
Tutorial for Measurements with Glass-Membrane pH Electrode
pH Convention Adopted by IUPAC and Supported by NIST
Liquid-Junction Potentials (LJP)
pKa Refinement by Weighted Nonlinear Regression
Molality to Molarity Conversion
References