4. Octanol–Water Partitioning

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch4

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Octanol–Water Partitioning, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch4

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • octanol–water partitioning and lipophilicity, “lipid-attraction”;
  • orally active, ammonium drugs, octanol–water partitioning;
  • log P determination methods;
  • log P, ionic strength dependence;
  • calculated versus measured log P, of research compounds

Summary

This chapter contains sections titled:

  • Overton–Hansch Model

  • Tetrad of Equilibria

  • Conditional Constants

  • log P Data Sources

  • log D Lipophilicity Profile

  • Ion-Pair Partitioning

  • Micro-log P

  • Methods for log P Determination

  • Dyrssen Dual-Phase Titration log P Method

  • Ionic Strength Dependence of log P

  • Temperature Dependence of log P

  • Calculated versus Measured log P of Research Compounds

  • log D versus pH Case Study: Procaine Structural Analogs

  • Database of Octanol–Water log PN, log PI, and log D7.4

  • References