5. Liposome–Water Partitioning

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch5

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Liposome–Water Partitioning, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch5

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • liposome–water partitioning, “biomimetic” lipophilicity;
  • tetrad of equilibria and SIP;
  • liposome diff to octanol diff functions of substituted phenols;
  • lipophilicity three indices, liposomes, IAM, octanol;
  • charged species, partitioning into liposomes

Summary

This chapter contains sections titled:

  • Biomimetic Lipophilicity

  • Tetrad of Equilibria and Surface Ion-Pairing (SIP)

  • Data Sources

  • Location of Drugs Partitioned into Bilayers

  • Thermodynamics of Partitioning: Entropy- or Enthalpy-Driven?

  • Electrostatic and Hydrogen Bonding in a Low Dielectric Medium

  • Water Wires, H+/OH Currents, and Permeability of Amino Acids and Peptides

  • Preparation Methods: MLV, SUV, FAT, LUV, ET

  • Experimental Methods

  • Prediction of log PMEM from log POCT

  • log DMEM, diff log PMEM, and Prediction of log PMEMSIP from log POCTI

  • Three Indices of Lipophilicity: Liposomes, IAM, and Octanol

  • Getting It Wrong from One-Point log DMEM Measurement

  • Partitioning into Charged Liposomes

  • pKaMEM Shifts in Charged Liposomes and Micelles

  • Prediction of Absorption from Liposome Partition Studies?

  • Database of log PMEM and log PMEMSIP

  • References