5. Liposome–Water Partitioning
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch5
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Liposome–Water Partitioning, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch5
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- liposome–water partitioning, “biomimetic” lipophilicity;
- tetrad of equilibria and SIP;
- liposome diff to octanol diff functions of substituted phenols;
- lipophilicity three indices, liposomes, IAM, octanol;
- charged species, partitioning into liposomes
Summary
This chapter contains sections titled:
Biomimetic Lipophilicity
Tetrad of Equilibria and Surface Ion-Pairing (SIP)
Data Sources
Location of Drugs Partitioned into Bilayers
Thermodynamics of Partitioning: Entropy- or Enthalpy-Driven?
Electrostatic and Hydrogen Bonding in a Low Dielectric Medium
Water Wires, H+/OH− Currents, and Permeability of Amino Acids and Peptides
Preparation Methods: MLV, SUV, FAT, LUV, ET
Experimental Methods
Prediction of log PMEM from log POCT
log DMEM, diff log PMEM, and Prediction of log PMEMSIP from log POCTI
Three Indices of Lipophilicity: Liposomes, IAM, and Octanol
Getting It Wrong from One-Point log DMEM Measurement
Partitioning into Charged Liposomes
pKaMEM Shifts in Charged Liposomes and Micelles
Prediction of Absorption from Liposome Partition Studies?
Database of log PMEM and log PMEMSIP
References