6. Solubility
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch6
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Solubility, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch6
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- ionizable drug solubility, pH-dependent measurement;
- solubility reactions, heterogeneous with slow equilibrium reach;
- DMSO effect correction by “Δ-SHIFT” method;
- solubility –pH profiles case studies;
- HTS measurement techniques
Summary
This chapter contains sections titled:
It's Not Just a Number
Why Is Solubility Measurement Difficult?
Mathematical Models for Solubility–pH Profiles
Experimental Methods
Correction for the DMSO Effect by the “Δ-Shift” Method
Case Studies (Solubility–pH Profiles)
Limits of Detection—Precision versus Accuracy
Data Sources and the “Ionizable-Drug Problem”
Database of log S0
References