6. Solubility

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch6

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Solubility, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch6

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • ionizable drug solubility, pH-dependent measurement;
  • solubility reactions, heterogeneous with slow equilibrium reach;
  • DMSO effect correction by “Δ-SHIFT” method;
  • solubility –pH profiles case studies;
  • HTS measurement techniques

Summary

This chapter contains sections titled:

  • It's Not Just a Number

  • Why Is Solubility Measurement Difficult?

  • Mathematical Models for Solubility–pH Profiles

  • Experimental Methods

  • Correction for the DMSO Effect by the “Δ-Shift” Method

  • Case Studies (Solubility–pH Profiles)

  • Limits of Detection—Precision versus Accuracy

  • Data Sources and the “Ionizable-Drug Problem”

  • Database of log S0

  • References