7. Permeability—PAMPA
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch7
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Permeability—PAMPA, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch7
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- permeability—PAMPA model;
- permeability measurement, predicting HJP and HIA;
- biological membranes, and lipid compositions;
- Iso-pH equations with membrane retention;
- PAMPA paramembrane water channels
Summary
This chapter contains sections titled:
Permeability in the Gastrointestinal Tract
Historical Developments in Permeability Models
Rise of PAMPA—A Useful Tool in Early Drug Discovery
PAMPA-HDM, -DOPC, -DS Models Compared
Modeling Biological Membranes
Permeability–pH Relationship and the Mitigating Effect of the Aqueous Boundary Layer
pKaFLUX-Optimized Design (pOD)
Cosolvent PAMPA
UV versus LC/MS Detection
Assay Time Points
Buffer Effects
Apparent Filter Porosity
PAMPA Errors: Intra-Plate and Inter-Plate Reproducibility
Human Intestinal Absorption (HIA) and PAMPA
Permeation of Permanently Charged Molecules
Permeation of Zwitterions/Ampholytes—In Combo PAMPA
PAMPA in Formulation: Solubilizing Excipient Effects
Database of Double-Sink PAMPA log P0, log Pm6.5, and log Pm7.4
Quick Start: Double-Sink PAMPA of Metoprolol
Permeability Equations
PAMPA Paramembrane Water Channels
References