8. Permeability: Caco-2/MDCK
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch8
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Permeability: Caco-2/MDCK, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch8
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- permeability, Caco-2/MDCK;
- permeability, cell-based assays using Caco-2 and MDCK;
- passive intrinsic permeability coefficients, Caco-2 and MDCK;
- Caco-2/MDCK passive permeability prediction model;
- Caco- 2/MDCK database and combo PAMPA prediction
Summary
This chapter contains sections titled:
Permeability in the Gastrointestinal Tract
Cell-Based In Vitro Permeability Model
In Situ Human Jejunum Permeability (HJP) Model
Passive Intrinsic Permeability Coefficients of Caco-2 and MDCK Compared
Theory (Stage 1): Paracellular Leakiness and Size Exclusion in Caco-2, MDCK, and 2/4/A1 Cell Lines
Theory (Stage 2): Regression Method for In Vitro Cellular Permeability
Case Studies of Cell-Based Permeability as a Function of pH
Human Jejunal Permeability Predicted Directly from Caco-2/MDCK
Caco-2/MDCK Database and Its In Combo PAMPA Prediction
References