8. Permeability: Caco-2/MDCK

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch8

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Permeability: Caco-2/MDCK, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch8

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • permeability, Caco-2/MDCK;
  • permeability, cell-based assays using Caco-2 and MDCK;
  • passive intrinsic permeability coefficients, Caco-2 and MDCK;
  • Caco-2/MDCK passive permeability prediction model;
  • Caco- 2/MDCK database and combo PAMPA prediction

Summary

This chapter contains sections titled:

  • Permeability in the Gastrointestinal Tract

  • Cell-Based In Vitro Permeability Model

  • In Situ Human Jejunum Permeability (HJP) Model

  • Passive Intrinsic Permeability Coefficients of Caco-2 and MDCK Compared

  • Theory (Stage 1): Paracellular Leakiness and Size Exclusion in Caco-2, MDCK, and 2/4/A1 Cell Lines

  • Theory (Stage 2): Regression Method for In Vitro Cellular Permeability

  • Case Studies of Cell-Based Permeability as a Function of pH

  • Human Jejunal Permeability Predicted Directly from Caco-2/MDCK

  • Caco-2/MDCK Database and Its In Combo PAMPA Prediction

  • References