9. Permeability: Blood–Brain Barrier

  1. Alex Avdeef1,2

Published Online: 7 MAY 2012

DOI: 10.1002/9781118286067.ch9

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

How to Cite

Avdeef, A. (2012) Permeability: Blood–Brain Barrier, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch9

Author Information

  1. 1

    Cambridge, Massachusetts, USA

  2. 2

    Boston, Massachusetts, USA

Publication History

  1. Published Online: 7 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781118057452

Online ISBN: 9781118286067

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Keywords:

  • permeability, Blood–Brain Barrier (BBB);
  • permeability data using endothelial cell models of BBB;
  • BBB, key element in CNS drug access;
  • biophysical analysis of in vitro endothelial cell models;
  • PAMPA–BBB, molecules affected by carrier-mediated process

Summary

This chapter contains sections titled:

  • The Blood–Brain Barrier: A Key Element for Drug Access to the Central Nervous System

  • The Blood–Brain Barrier

  • Noncellular BBB Models

  • In Vitro BBB Cell-Based Models

  • In Vivo BBB Models

  • Paradigm Shift

  • In Silico BBB Models

  • Biophysical Analysis of In Vitro Endothelial Cell Models

  • In Situ Brain Perfusion Analysis of Flow

  • In Combo PAMPA–BBB Model for Passive BBB Permeability

  • References