9. Permeability: Blood–Brain Barrier
Published Online: 7 MAY 2012
DOI: 10.1002/9781118286067.ch9
Copyright © 2012 John Wiley & Sons, Inc.
Book Title
Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition
Additional Information
How to Cite
Avdeef, A. (2012) Permeability: Blood–Brain Barrier, in Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118286067.ch9
Publication History
- Published Online: 7 MAY 2012
- Published Print: 11 MAY 2012
ISBN Information
Print ISBN: 9781118057452
Online ISBN: 9781118286067
- Summary
- Chapter
- References
Keywords:
- permeability, Blood–Brain Barrier (BBB);
- permeability data using endothelial cell models of BBB;
- BBB, key element in CNS drug access;
- biophysical analysis of in vitro endothelial cell models;
- PAMPA–BBB, molecules affected by carrier-mediated process
Summary
This chapter contains sections titled:
The Blood–Brain Barrier: A Key Element for Drug Access to the Central Nervous System
The Blood–Brain Barrier
Noncellular BBB Models
In Vitro BBB Cell-Based Models
In Vivo BBB Models
Paradigm Shift
In Silico BBB Models
Biophysical Analysis of In Vitro Endothelial Cell Models
In Situ Brain Perfusion Analysis of Flow
In Combo PAMPA–BBB Model for Passive BBB Permeability
References