31. MicroRNAs in Liver Diseases

  1. Charles H. Lawrie
  1. Patricia Munoz-Garrido1,
  2. Marco Marzioni2,
  3. Elizabeth Hijona1,
  4. Luis Bujanda1 and
  5. Jesus M. Banales3

Published Online: 1 NOV 2013

DOI: 10.1002/9781118300312.ch31

MicroRNAs in Medicine

MicroRNAs in Medicine

How to Cite

Munoz-Garrido, P., Marzioni, M., Hijona, E., Bujanda, L. and Banales, J. M. (2013) MicroRNAs in Liver Diseases, in MicroRNAs in Medicine (ed C. H. Lawrie), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118300312.ch31

Author Information

  1. 1

    Division of Hepatology and Gastroenterology, Biodonostia Research Institute, San Sebastián, Spain

  2. 2

    Department of Gastroenterology, “Università Politecnica delle Marche,” Ancona, Italy

  3. 3

    IKERBASQUE, Basque Foundation of Science, Bilbao, Spain

Publication History

  1. Published Online: 1 NOV 2013
  2. Published Print: 2 DEC 2013

ISBN Information

Print ISBN: 9781118300398

Online ISBN: 9781118300312

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Keywords:

  • microRNAs;
  • liver;
  • biliary tract;
  • hepatocytes;
  • cholangiocytes;
  • viral hepatitis;
  • alcoholic liver disease (ALD);
  • non-alcoholic fatty liver disease (NAFLD);
  • non-alcoholic steatohepatitis (NASH);
  • drug-induced liver injury (DILI)

Summary

The etiopathogenesis and pathophysiology of liver diseases is very heterogeneous and may affect different cell types within the liver. However, recent studies are revealing the important contribution of miRNAs to the pathogenesis liver diseases. MicroRNAs, small non-coding endogenous RNAs able to posttranscriptionally regulate gene expression, have been associated with pathophysiological processes in different organs and cell types, being postulated as potential targets for diagnosis and therapy. In this chapter, the knowledge regarding the role of microRNAs in the development and/or progression of liver diseases, as well as their potential therapeutic role, are reviewed, and the most relevant findings in this promising field of hepatology are highlighted.