20. Transplant Histopathology

  1. Iain A. M. MacPhee2,3 and
  2. Jiří Froněk4,5
  1. Eva Honsová

Published Online: 11 MAY 2012

DOI: 10.1002/9781118305294.ch20

Handbook of Renal and Pancreatic Transplantation

Handbook of Renal and Pancreatic Transplantation

How to Cite

Honsová, E. (2012) Transplant Histopathology, in Handbook of Renal and Pancreatic Transplantation (eds I. A. M. MacPhee and J. Froněk), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118305294.ch20

Editor Information

  1. 2

    Division of Clinical Sciences: Renal Medicine, St. George's Healthcare NHS Trust, University of London, London, UK

  2. 3

    Department of Renal Medicine and Transplantation, St. George's Healthcare NHS Trust, Blackshaw Road, London, UK

  3. 4

    Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

  4. 5

    2nd Medical Faculty, Charles University, Prague, Czech Republic

Author Information

  1. Clinical and Transplant Pathology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Publication History

  1. Published Online: 11 MAY 2012
  2. Published Print: 6 JUN 2012

ISBN Information

Print ISBN: 9780470654910

Online ISBN: 9781118305294

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Keywords:

  • Kidney transplantation;
  • pancreas transplantation;
  • histopathology;
  • rejection

Summary

Renal and/or pancreas graft biopsy provides critical information enabling diagnosis not only of various types of rejection changes, but also of the large number of conditions that can affect the allograft, sometimes in combination, and that can lead to graft dysfunction. Rejection still remains one of the main reasons for graft loss, especially in the late period after transplantation. The chapter provides key information about histopathology of T-cell-mediated and antibody-mediated rejection changes, and also other non-rejection-associated conditions including polyomavirus nephropathy. The current update of the Banff schema from 2009 is used for classification of renal and pancreas graft pathology. Pictures illustrating typical histopathological features also accompany the text.