6. Transition Metal-Catalyzed Synthesis of Five- and Six-Membered Heterocycles

  1. Matthew L. Crawley2 and
  2. Barry M. Trost3
  1. Cheol K. Chung1 and
  2. Matthew L. Crawley2

Published Online: 10 MAY 2012

DOI: 10.1002/9781118309872.ch6

Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

How to Cite

Chung, C. K. and Crawley, M. L. (2012) Transition Metal-Catalyzed Synthesis of Five- and Six-Membered Heterocycles, in Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective (eds M. L. Crawley and B. M. Trost), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118309872.ch6

Editor Information

  1. 2

    Main Line Health, Berwyn, Pennsylvania, USA

  2. 3

    Stanford University, Stanford, California, USA

Author Information

  1. 1

    Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, USA

  2. 2

    Main Line Health, Berwyn, Pennsylvania, USA

Publication History

  1. Published Online: 10 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470631324

Online ISBN: 9781118309872

SEARCH

Keywords:

  • five- and six-membered heterocycles, transition metal-catalysis;
  • Heck cyclization;
  • migratory insertion-induced cyclization;
  • cyclization via carbon–heteroatom coupling;
  • ring-closing metathesis

Summary

This chapter contains sections titled:

  • Introduction and Background

  • Heck Cyclization

  • Cyclization Induced by Cross-Coupling

  • Migratory Insertion-Induced Cyclization

  • Cyclization via Carbon-Heteroatom Coupling

  • Cycloisomerization

  • Ring-Closing Metathesis

  • Other Cyclizations of Interest

  • Conclusion

  • References