10. Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer

  1. Thomas N. Seyfried

Published Online: 29 MAY 2012

DOI: 10.1002/9781118310311.ch10

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

How to Cite

Seyfried, T. N. (2012) Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118310311.ch10

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9780470584927

Online ISBN: 9781118310311

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Keywords:

  • respiratory insufficiency, the RTG response and origin of cancer;
  • RTG response, epigenetic for nuclear genomic stability;
  • RTG response and ATP, glycolysis or glycolysis, glutamine metabolism;
  • inflammation and mitochondrial LOH, respiratory damage to carcinogenesis;
  • HIF-1α stability, pseudo-hypoxia, glycolytic, and respiratory insufficiency

Summary

This chapter contains sections titled:

  • The Retrograde (RTG) Response: An Epigenetic System Responsible for Nuclear Genomic Stability

  • Inflammation Injures Cellular Respiration

  • Hypoxia-Inducible Factor (HIF) Stability is Required for the Origin of Cancer

  • Mitochondria and the Mutator Phenotype

  • Calcium Homeostasis, Aneuploidy, and Mitochondrial Dysfunction

  • Mitochondrial Dysfunction and Loss of Heterozygosity (LOH)

  • Tissue Inflammation, Damaged Respiration, and Cancer

  • References